Clinician’s guide to integrative peptide activation micro blend and nutrient supplementation with alive innovations.

Dr. Michael Rahman, PhD, MD(gy), ND

Introduction

Alive Innovations offers a comprehensive list of health product designed to enhance peptide activation and support various phases of metabolic and digestive health. This article explores the synergy between specific products within the Alive Innovations line, focusing on GLP-1 receptor agonists such as semaglutide, tirzepatide, and liraglutide, alongside supplemental stock support products like SB PRO, GI PRO, SLK PRO, and HydroMin. The approach is divided into phases to optimize organ function, metabolic response, and neurological health. A rational for the phases also follows.

Phase 1: Initial Induction Phase

Peptide Activation and GLP-1 Receptor Agonists GLP-1 receptor agonists (GLP-1 RAs) such as semaglutide (Ozempic, Rybelsus, Wegovy), tirzepatide (Mounjaro, Zepound), and liraglutide (Victoza, Saxenda) play a pivotal role in managing type 2 diabetes and obesity by mimicking incretin hormones. These peptides exert their effects through several mechanisms:

  1. Enhanced Insulin Secretion: GLP-1 RAs stimulate insulin release from pancreatic beta cells in a glucose-dependent manner. This means they increase insulin secretion when blood glucose levels are high, helping to lower postprandial glucose levels¹.
  2. Reduced Glucagon Secretion: These agonists suppress the secretion of glucagon, a hormone that raises blood glucose levels. By reducing glucagon levels, GLP-1 RAs help decrease hepatic glucose production².
  3. Delayed Gastric Emptying: GLP-1 RAs slow down the rate at which food leaves the stomach, leading to prolonged feelings of fullness and reduced appetite. This mechanism is particularly beneficial for weight management³.
  4. Cardiovascular Benefits: Clinical trials have demonstrated that GLP-1 RAs can reduce the risk of major adverse cardiovascular events (MACE), such as heart attack and stroke, in individuals with type 2 diabetes and cardiovascular disease⁴.

It is inherent to any blood sugar balancing strategy to discuss lifestyle and dietary modification with patients, and consider fundamental support of the glycemic control mechanisms using SB PRO, Stimulates Metabolism Lowers Blood Sugar, Proprietary Blend Of Antioxidants And Amino Acids, Provides Support For Proper Cell.

Highlights to the formula include the Chromium, Vanadium, Alpha Lipoic, Gymnema Leaf Extract, Guggul Extract and Bitter Melon Extract, name but a few; because of the property of this in conjunction with the onboarding of the incretin (peptide); it would be wise to start low and work up on the dosing from 1-3 capsules per meal. Continuous Glucose Monitoring (GGM) has the advantage her of providing that real time metric of change.

Digestive Support

During the initial phase, it’s crucial to support the digestive organs, including the liver, focusing on gut motility and satiety centers influenced by stretch eceptors and probiotic balance. Alive Innovation’s GI PRO and SLK PRO are formulated to enhance gut health and liver function and aid motility, ensuring efficient nutrient absorption and a balanced microbiome. This combination can also help prevent the constipation or diarrhea that is common with induction.

Other specific Supplemental Support
  • HydroMin: This formula contains B vitamins (B1, B3, B6, B12) to combat nausea and support fluid and electrolyte balance, essential during the initial phase of weight reduction where fluid loss is significant.
  • B-12 Supplementation: Ensuring adequate levels of Vitamin B-12 is critical for neurological function and overall metabolic health.
Phase 2: Maintenance Phase
Metabolic Enhancement
Meta pro As the focus shifts from GI support, strengthening metabolic responses becomes paramount. In addition to the following products like MITO PRO Micro Blend and META PRO Micro Blend are designed to enhance mitochondrial function and metabolic pathways:
  • MITO PRO Micro Blend: Contains manganese, selenium, B-complex vitamins, copper, and Krebs cycle intermediates to support mitochondrial efficiency. Mitochondria are crucial for energy production, and enhancing their function can lead to improved metabolic rates and energy levels⁵.
Phase 3: Post-Induction Phase
Neurological and endocrine Support

Post-treatment, supporting the brain and neurological systems becomes essential to sustain behavioral changes and neuroplasticity induced by peptide treatments. Products such as FML PRO Micro Blend and ML PRO Micro Blend, although classically formulated for endocrine support are axis modifiers for the hypothalamus and pituitary – as components of the neuro-endocrine system. Additional support can be provided by micro blends like

NEURO PRO and NRVS PRO:

NEURO PRO and NRVS PRO Micro Blend These blends contain ingredients to enhance dopamine and related neuroplasticity and support neurological functions, crucial for hypothalamus reset of appetite and satiety. Enhanced neuroplasticity helps consolidate behavioral changes and supports long-term weight management strategies⁷. Lion’s Mane Mushroom: This natural upplement can further promote neuroplasticity and cognitive function, aiding in the overall neurological support during the post-induction phase. (Found in the Custom Complete)

Neuro pro
Justification for Phased Approach

The phased approach to integrating peptide activation and nutrient supplementation is rooted in scientific and clinical evidence that emphasizes targeted support at different stages of treatment. Initially, focusing on gastrointestinal (GI) health is essential because GLP-1 receptor agonists significantly influence gut motility and satiety through mechanisms involving delayed gastric emptying and enhanced incretin activity. Supporting the digestive system with products like GI PRO and SLK PRO ensures that patients can maximize the therapeutic benefits of GLP-1 RAs while mitigating common gastrointestinal side effects related especially to disturbed hepatobiliary function⁸.

During the maintenance phase, the emphasis shifts to metabolic support. This is because the body undergoes significant metabolic adaptations following the initial induction phase, necessitating enhanced mitochondrial function and optimized glucose and lipid metabolism. Products like MITO PRO Micro Blend and META PRO Micro Blend are designed to meet these metabolic demands by providing essential cofactors and nutrients that support mitochondrial efficiency and overall metabolic health⁹.

In the post-induction phase, neurological support becomes crucial. Peptide treatments such as GLP-1 RAs have been shown to impact neuroplasticity and brain function, particularly in regions associated with appetite regulation and satiety. Supporting neurological health with products like Micro blends NEURO PRO, NRVS PRO, and Lion’s Mane Mushroom helps reinforce behavioral changes and maintain the hypothalamus’s reset of appetite signals, which is critical for long-term success in weight management and metabolic health¹⁰.

Conclusion

The strategic use of Alive Innovations products in conjunction with GLP-1 receptor agonists facilitates a comprehensive approach to weight management and metabolic health. By supporting digestive health initially, enhancing metabolic pathways during maintenance, and focusing on neurological support post-treatment, this phased approach ensures holistic health improvements. Of course, it goes without saying that counselling on food choices and behaviour and physical activity modification all are lifestyle necessities to enhance clinical outcome.

Phase 1: Initial Induction Phase lasting (initial 3 months) SBPRO maybe used through out course of treatment
Objective
Action
Product
Mechanism
References
Blood sugar support
Enhance metabolism
SB Pro
Stimulates receptor reset and endogenous insulin production
Peptide Activation
Administer GLP1 receptor agonists
Semaglutide, Tirzepatide,Liraglutide
Stimulates insulin secretion, reduces glucagon, delays gastric emptying, provides cardiovascular benefits
Vilsbøll et al., 2012; Nauck, 2016
Digestive Support
Enhance gut motility and health
GI Pro, SLK Pro
Improves nutrient absorption, liver support ; balances microbiome
Health.com, 2023
Combat Nausea
Provide fluid and electrolyte balance
Hydromin
Contains B vitamins (B1, B3, B6, B12) to reduce nausea and support hydration
Pharma News Intel, 2023
Neurological Support
Supplement with B-12
B-12 Supplementation
Ensures adequate B12 levels for neurological and metabolic health
Secher et al., 2014
Clinical Protocol Chart
Phase 2: Maintenance (post induction) Phase (lasting 6-12 plus months)
Objective
Action
Product
Mechanism
References
Metabolic Enhancement
Support mitochondrial function and metabolic pathways
Mitopro Micro Blend
Contains manganese, selenium, B-complex vitamins, copper, and Krebs cycle intermediates
Zhou et al., 2021; Wallace, 2005
Enhance Metabolism
Improve glucose and lipid metabolism, enhance insulin sensitivity
Metapro Micro Blend
Balances ATP production, reduces insulin resistance, supports metabolic health
Diabetes Therapy, 2022
Clinical Protocol Chart
Phase 3: : Stabilization Phase (lasting 12 months, can begin while still on peptide and continue post treatment)
Objective
Action
Product
Mechanism
References
Neurological Support
Support brain function and neuroplasticity
Neuro Pro Micro blend, NRVS Pro Micro blend, Lion’s Mane Mushroom
Enhances neuroplasticity, supports hypothalamus reset of appetite and satiety
Holt & Trapp, 2016; Secher et al., 2014
Consolidate Behavioral Changes
Reintroduce initial neuroendocrine support products to reinforce changes
FML Pro Micro Blend, ML Pro Micro Blend
Supports long-term neurological health and behavioral change consolidation
Health.com, 2023
References
  1. Vilsbøll, T., Christensen, M., Junker, A. E., Knop, F. K., & Gluud, L. L. (2012). Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and metaanalyses of randomised controlled trials. BMJ, 344, d7771. BMJ
  2. Nauck, M. A. (2016). Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. The Lancet Diabetes & Endocrinology, 4(3), 207-217. The Lancet Diabetes & Endocrinology
  3. Health.com. (2023). Overview of GLP-1 Receptor Agonists. Health.com
  4. Pharma News Intel. (2023). Pharma News Intel
  5. Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., … & Bagger, J. I. (2014). The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. The Journal of Clinical Investigation, 124(10), 4473- 4488. The Journal of Clinical Investigation
  6. Zhou, Q., Lin, Y., Guo, Y., Chen, Y., & Xing, D. (2021). Mitochondrial dynamics: overview of mitochondrial fission and fusion and related genetic diseases. Acta Biochimica et Biophysica Sinica, 53(2), 198-210. Acta Biochimica et Biophysica Sinica
  7. Wallace, D. C. (2005). A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annual Review of Genetics, 39, 359-407. Annual Review of Genetics
  8. Diabetes Therapy. (2022). An Overview of Metabolic Health and Supplementation. Diabetes Therapy 8
  9. Holt, M. K., & Trapp, S. (2016). The physiological role of the brain GLP-1 system in stress. Cogent Biology, 2(1), 1229086. Cogent Biology
  10. Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., … & Bagger, J. I. (2014). The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. The Journal of Clinical Investigation, 124(10), 4473- 4488. The Journal of Clinical Investigation
Disclaimer

The information provided in this article is for educational purposes only and should not be construed as medical advice. Always consult with a healthcare professional before starting any new treatment regimen, especially if you have existing health conditions or are taking other medications. The efficacy and safety of supplements and medications can vary based on individual health profiles and conditions.